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1 劉貽章 -美國新澤西州州立羅格斯大學教授

  簡歷

  姓名: 劉貽章 (Alice Y.-C. Liu)

  生日:1948 年7 月12 日

  國籍:美國

  學習簡歷: Mount Sinai 醫學院生物藥理博士

  學士B.S. 香港中文大學Chinese University of Hong Kong, 1969

  博士Ph.D. 紐約西奈山醫學院Mount Sinai School of Medicine, 1974

  博士後Postdoc, 耶魯大學醫學院藥理學系Yale Medical School, pharmacology 1974-77

  專業職務: 美國新澤西州州立羅格斯大學教授

  從事專業: 本科生老師,博士導師

  任職單位: 羅格斯大學,細胞生物學及神經科學學系。

  工作簡歷:

  1977-1984 助教授,哈佛大學醫學院藥理學系

  1984-1989 副教授,新澤西州立羅格斯大學生物科學系

  1989-1998 正教授,新澤西州立羅格斯大學生物科學系

  1994-1999 主任,羅格斯大學及羅伯特強生醫學院細胞及發育生物學研究院

  1998- 目前 正教授,新澤西州立羅格斯大學細胞生物及神經科學系

  科研項目

  我們實驗室長期以來從事分子生物學的研究工作。近年來的研究工作主要集中在HSF1 在神經

  細胞生長及凋亡的功能。

  實驗室主要科研項目如下:

  (1) 轉錄因子HSF1 在細胞體內的氧化還原調控及功能。

  (2) 伴侶蛋白( Chaperones)及蛋白摺疊對神經細胞的保護作用。

  (3) 神經細胞中HSF1 的調控與功能。

  主要學術成就

  我們實驗室長期以來接受美國國家衛生總署(NIH)及國家科學基金會NSF 的支助。我們是最

  早發現熱應激反應與細胞老化與有關的實驗室。這項結果已為許多實驗室證明,並認為是生物

  老化的一個重要的分子標誌。我們實驗室開創研究HSF1 在神經受創復原的作用對脊髓再生作

  出理論上的貢獻。我們實驗室畢業有10 位博士,12 位碩士,並訓練了8 位後博士。

  重要學術活動

  1982 Member, Special Study Section, NCI, NIH

  1982 Member, Basic Neuropsychology Research Review subcommittee, NIMH

  1984-1988 Member, Pharmacological Sciences Review Committee, NIGMS, NIH

  1987 Member, Review Team for NIH Center Grant application from U. Calif – San Francisco

  1989-1995 Member, Cell Biology Panel, National Science Foundation

  1993 Member, Biochemistry and Endocrinology Study Section, Amer. Cancer Soc.

  1990-2001 Member, Editorial Board, Biological Signals

  1999, 2000, 2003 & 2004 Member, Center for Scientific Review Special Emphasis Panel, NIH

  1990-present Member, Basic Research Advisory Group, NJ Commission on Cancer Research

  2007 Member, Center for Scientific Review Special Emphasis Panel, National Institutes of Health

  2009 Member, Brain I study section, American Heart ASSOC.

  2009 Member, Center for Scientific Review Special Emphasis Panel, National Institutes of Health

  2010 Member, Brain I study section, American Heart Assoc.

  獎勵:

  1972 New York Board of Higher Education Award

  1974-1977 NIH Post-doctoral Fellowship (1F22AM01521)

  1977-1979 Medical Foundation Fellowship

  1982-1985 American Cancer Society Scholar Award

  學術論文: (peer reviewed journals)

  1. Liu, A. Y.-C. and Bentley, P. J. (1971) A comparison of the toxicity of ouabain in vivo and in vitro in

  the frog, Rana pipiens, and the toad, Bufo marinus, Comp. Gen. Pharmacol. 2: 476-478.

  2. Liu, A. Y.-C. and Mittag, T. W. (1974) Membrane-bound acetylcholinesterase: comparison of

  enzymes in sarcoplasmic reticulum and sarcolemma from striated muscle. Mol. Pharmacology

  10: 283-292.

  3. Liu, A. Y.-C. and Greengard, P. (1974) Aldosterone-induced increase in protein phosphatase

  activity of toad bladder. Proc. Natl. Acad. Sci., U.S.A, 71: 3869-3873.

  4. Liu, A. Y.-C. and Greengard, P. (1976) Regulation by steroid hormones of phosphorylation of a

  specific protein common to several target organs. Proc. Natl. Acad. Sci., U.S.A. 73: 568-572.

  5. Walter, U., Uno, I., Liu, A. Y.-C. and Greengard, P. (1977) Identification, characterization, and

  quantitative measurement of cyclic AMP receptor proteins in cytosol of various tissues using a

  photoaffinity ligand. J. Biol. Chem. 252: 6494-6500.

  6. Walter, U., Uno., I., Liu, A. Y.-C. and Greengard, P. (1977) Study of autophosphorylation of

  isoenzymes of cyclic AMP-dependent protein kinases. J. Biol. Chem. 252: 6588-6590.

  7. Liu, A. Y.-C. (1980) Role of cyclic AMP-dependent protein kinase in the induction of tyrosine

  aminotransferase. J. Biol. Chem. 255: 4421-4429.

  8. Kiu, A. Y.-C., Fiske, W.W. and Chen, K.Y. (1980) Regulation of cyclic adenosine 3':5'-

  monosphophate-binding protein in N-18 mouse neuroblastoma cells. Cancer Research 40:

  4100-4108.

  9. Culpepper, J. and Liu, A. Y.-C. (1981) Induction of tyrosine aminotransferase by cAMP captured in

  phospholipid vesicles. J. Cell Biol. 88: 89-95.

  10. Liu, A. Y.-C., Walter, U. and Greengard, P. (1981) Steroid hormones may regulate

  autophosphorylation of cyclic adenosine 3':5'-monophosphate-dependent protein kinase in

  target tissues. Eur. J. Biochem. 114: 539-548.

  11. Liu, A. Y.-C., Chan, T. and Chen, K. Y. (1981) Specific induction of regulatory subunit of type I

  cAMP-dependent protein kinase in differentiated N-18 mouse neuroblastoma cells. Cancer

  Research 41: 4579-4587.

  12. Smith, J. D. and Liu, A. Y.-C. (1981) Lectins induce tyrosine aminotransferase in hepatoma cells.

  Science 214: 799-800.

  13. Chen, K. Y. and Liu, A Y.-C. (1981) Differences in polyamine metabolism of the undifferentiated

  and differentiated neuroblastoma cells. FEBS Letters 134: 71-74.

  14. Chen, K. Y., Prespe, J., Parken, N. and Liu, A. Y.-C. (1982) Changes of ornithine decarboxylase

  activity and polyamine content upon differentiation of mouse NB-15 neuroblastoma cells. J.

  Cell. Physiol. 110: 285-290.

  15. Liu, A. Y.-C. (1982) Differentiation-specific increase of cAMP-dependent protein kinase in the 3T3-

  L1 cells. J. Biol. Chem. 257: 298-306.

  16. Chen, K. Y. and Liu, A. Y.-C. (1983) Role of polyamines in the differentiation of mouse

  neuroblastoma cells. Advances in Polyamine Research, Volume 4 (Bachrach, U., Kaye, A.

  and Chayen, R., eds) pp. 743-755.

  17. Chen, K. Y. and Liu, A. Y.-C. (1983) Differences in the mode of regulation of ornithine

  decarboxylase and tyorsine aminotransferase in H-35 rat hepatoma cells shown by varying the

  medium composition. Biochem. Biophys. Acta. 755: 244-252.

  18. Chen, K. Y., Nau, D. and Liu, A. Y.-C. (1983) Effects of inhibitors of ornithine decarboxylase on

  the differentiation of mouse neuroblastoma cells. Cancer Research 43: 2812-2818.

  19. Culpepper, J. A. and Liu, A. Y.-C. (1983) Pretranslational control of tyrosine aminotransferase

  synthesis by 8-bromo-cyclic AMP in H-4 rat hepatoma cells. J. Biol. Chem. 258: 13812-13818.

  20. Liu, A. Y.-C. (1984) Modulation of the function and activity of cAMP-dependent protien kinase by

  steroid hormones and its possible role in the mechanism of steroid hormone action. Trends in

  Pharmacological Science 5: 106-108.

  21. Liu, A. Y.-C. (1984) Modulation of the function and activity of cAMP-dependent protien kinase by

  steroid hormones and its possible role in the mechanism of steroid hormone action. In

  Receptors, Again (Lamble, J. W. and abbot, A. C. eds), Elsevier Publications, pp. 279-283.

  22. Liu, A. Y.-C. and Chen, K. Y. (1985) Differential effects of the phorbol ester tumor promotor, PMA,

  on the morphological and biochemical differentiation of N-18 mouse neuroblastoma cells. J.

  Cell. Physiol. 125: 387-392.

  23. Liu, A. Y.-C., Chang, Z. F. and Chen, K. Y. (1986) Increased level of cAMP-dependent protein

  kinase in aging human lung fibroblasts. J. Cell. Physiol. 128: 149-154.

  24. Chen, K. Y., Chang, Z. F. and Liu, A. Y.-C. (1986) Changes of serum-induced ornithine

  decarboxylase activity and putrescine content during aging of IMR-90 human diploid

  fibroblasts. J. Cell. Physiol. 129: 142-146.

  25. Liu, A. Y.-C., Kamalakannan, V. and Chen, K. Y. (1987) Identification of functional cAMPdependent

  protein kinase in a "neurite-minus" mouse neuroblastoma cell line. Biochem.

  Biophys. Acta. 928: 235-239.

  26. Liu, A. Y.-C., Kamalakannan, V. and Lin, Z. (1987) Induction of the RI cAMP-binding protein in the

  "neurite-minus" N1A-103 mouse neuroblastoma cell line. Biochem. Biophys Res. Commun.,

  148: 350-356.

  27. Liu, A. Y.-C., Lin, Z., Kamalakannan, V. and Chen, K. Y. (1988) Induction and quantitation of the

  RI cAMP-binding protein in clonal mouse neuroblastoma cell lines: Evidence that the increase

  in RI is not linked to neurite outgrowth. J. Neuroscience Research 19: 303-311.

  28. Liu, A. Y.-C. and Lin, Z. (1988) Specificity of the action of cAMP agonists in the induction of RI

  cAMP-binding protein in mouse neuroblastoma cells. Biochemical Pharmacology 37: 2005-

  2011.

  29. Smith, J. D. and Liu, A. Y.-C. (1988) The induction, desensitization, and deinduction of tyrosine

  aminotransferase by 8-bromo-cAMP in H-4 rat hepatoma cells. Biochem. J., 251: 261-267.

  30. Meyer, S., Lin, Z. and Liu, A. Y.-C. (1988) Neurite extension and increased expression of RI

  cAMP-binding protein in ouabain-resistant neuroblastoma mutants. J. Neurochem., 51: 950-

  959.

  31. Smith, J. D. and Liu, A. Y.-C. (1988) Increased turnover of messenger RNA encoding tyrosine

  aminotransferase can account for the desensitization and de-induction of tyrosine

  aminotransferase by 8-bromo-cAMP treatment and removal. embo Journal 7: 3711-3716.

  32. Liu, A. Y.-C., Lin, Z., Choi, H. S., Sorhage, F. and Li, B. (1989) Attenuated heat shock gene

  expression in aging diploid fibroblasts. J. Biol. Chem. 264: 12037-12045.

  33. Liu, A. Y.-C., Bae-Lee, M. S., Choi, H. S. and Li, B. (1989) Heat shock induction of HSP 89 is

  regulated in cellular aging. Biochem. Biophys. Res. Commun. 162: 1302-1310.

  34. Chen. K. Y., Chang, Z. F., Pang, J. H., He, G. S. and Liu, A. Y.-C. (1989) Polyamine metabolism

  and cell-cycle-dependent gene expression in IMR-90 human diploid fibroblasts during

  senescence in culture. Experimental gerontology 24: 523-537.

  35. Choi, H. S., Lin, Z., Li, B. and Liu, A. Y.-C. (1990) Age-dependent decrease in the heat-inducible

  DNA sequence-specific binding activity in human diploid fibroblasts. J. Biol. Chem., 265:

  18005-18011.

  36. Liu, A. Y.-C., Choi, H. S. and Bae-Lee, M. S. (1990) Decreased heat shock response upon

  adipose differentiation of 3T3-L1 cells. Biochem. Biophys. Res. Commun. 172: 1-7.

  37. Choi, H. S., Li, B., Lin, Z., and Liu, A. Y.-C. (1991) cAMP and cAMP-dependent protein kinase

  regulate the human hsp 70 gene promoter activity. J. Biol. Chem. 266: 11858-11865.

  38. Liu, A. Y.-C., Li, B., Choi, H. S. and Lee, Y.- K. (1991) Molecular events involved in transcriptional

  activation of heat shock genes become progressively refractory to heat stimulation during

  aging of human diploid fibroblasts. J. Cell. Physiol. 149: 560-566.

  39. Zhang, H. and Liu, A. Y.-C. (1992) Tributyltin is a potent inducer of the heat shock response in

  human diploid fibroblasts. J. Cell. Physiol., 153: 460-466.

  40. Chang N. T. and Liu, A. Y.-C. (1992) The heat induced hsp 70 promoter activity is negatively

  regulated by serine phosphatases: evidence from the effects of okadaic acid. Biological

  Signals, 1: 300-312.

  41. Chang, N. T., Huang, L. E. and Liu, A. Y.-C. (1993) Okadaic acid markedly potentiated the heatinduced

  hsp 70 promoter activity. J. Biol. Chem., 268: 1436-1439.

  42. Liu, A. Y.-C., Bian, H. J., Huang, L. E. and Lee, Y. K. (1994) Transient cold shock induces the

  heat shock response upon recovery at 37°C in human cells. J. Biol. Chem. 269: 14769-14775.

  43. Huang, L. Eric, Zhang, H. Bae, S. W. and Liu, A. Y.-C. (1994) Thiol reducing reagents inhibit the

  heat shock response: involvement of a Redox mechanism in the heat shock signal transduction

  pathway. J. Biol. Chem., 269: 30718-30725.

  44. Huang, L. Eric, Caruccio, L., Liu, A. Y.-C. and Chen, K. Y. (1995) Rapid activation of the heat

  shock transcription factor, HSF1, by hypo-osmotic stress in mammalian cells. Biochem.

  Journal, 307: 347-352.

  45. Liu, A. Y.-C., Lee, Y. K., Manalo, D., and Huang, L. E. (1996) Attenuated heat shock

  transcriptional response in aging: Molecular mechanisms and implications in the biology of

  aging. In Stress-inducible Cellular Responses (Ulrich Feige, Richard I. Morimoto, Ichiro

  Yahara, and Barbara S. Polla, eds.), Birkhauser/Springer.

  46. Lee, Y. K., Manalo, D. and Liu, A. Y.-C. (1996) Regulation and function of the heat shock

  transcription factor in cell aging. Biological Signals 5: 180-191.

  47. Liu, A. Y.-C., Chen, K. Y. and Denhardt, D. T. (1996) Transcription Factors and Cell Aging,

  Kargar Publishing, Basal, Switzerland.

  48. Caruccio, L., Bae, S., Liu, A. Y.-C. and Chen, K. Y. (1997) Rapid activation of the heat shock

  transcription factor, HSF1, by hyper- and hypo-osmotic stress in mammalian cells. Biochemical

  Journal, I327: 341-347.

  49. Chen, K. Y. and Liu, A. Y.-C. , Editors (1997) Biochemistry and function of hypusine formation on

  eukaryotic translation initiation factor 5A. Kargar Publishing, Basal, Switzerland.

  50. Chen, K.Y., Lu, Jiebo and Liu, A.Y.-C. ( 2000) The activation of trans-acting factors in response to

  hypo- and hyper-osmotic stress in mammalian cells. In " Environmental Stressors and Gene

  Responses." (eds. Storey, K. B., and Storey, J), Elsevier Science Press, CT.

  51. Lu, J.B., Park, J., Liu, A.Y-C. and Chen, K.Y. (2000) Osmotic stress-induced activation of HSF1

  DNA binding activity is dramatically attenuated in senescent human cells. J. Cell. Physiol.

  184:183-190.

  52. Park, Jeonghyeon and Liu, A. Y.-C. (2000) Pervanadate induces the hyperphosphorylation but

  not the activaton of human heat shock factor 1. J. Cell. Physiol. 185: 348-357.

  53. Park, Jeonghyeon and Liu, A. Y.-C. (2001) c-Jun-N-terminal kinase phosphorylates the HSF1

  transcriptional activation domain : Role of JNK in the regualtion of the heat shock response. J.

  Cell. Biochemistry 82: 326-338.

  54. Manalo, D. J. and Liu, A. Y.-C. (2001) Resolution, detection, and characterization of redox

  conformers of human HSF1. J. Biol. Chem. 276: 23554-23561.

  55. Manalo, D. J., Lin, Z. and Liu, A. Y.-C. (2002) Redox-dependent regulation of the function and

  conformation of human HSF1. Biochemistry, 41: 2580-2588.

  56. Lin, Z., Fan, Huang, F., Ma, Z-F., Xu, K., and Liu, A. Y.-C. (2003) Redox-dependent changes in

  structure and function of hHSF1. Acta Biochemica et Biophysica Sinica. 35: 542-547.

  57. Lin, Z., Fan, Huang, F., Ma, Z-F., Xu, K., and Liu, A. Y.-C. (2003) Human heat shock

  transcription factor 1 may have integrated redox chemistry of cysteine sulfhydryl into its functional

  responses. Chin J. Geriatr. 22: 417-420.

  58. Khalil, S., Luciano, J., Chen, W., Liu, A. Y.-C. (2006) Dynamic regulation and involvement of the

  heat shock transcriptional response in arsenic carcinogenesis. J. Cell Physiology. 207:562-569.

  59. Oza J, Yang JX, Chen KY and Liu AY-C. (2008) Changes in the regulation of heat shock gene

  expression in neural differentiation. Cell Stress & Chaperones 13(1): 73-84.

  60. Yang JX, Oza J, Bridges K, Chen KY, Liu AY-C. (2008) Neural differentiation and the attenuated

  heat shock response. Brain Research 1203: 39-50.

  61. Yang JX, Bridges K, Chen KY, Liu AY-C. (2008) Riluzole increases the amount of latent HSF1

  for an amplified heat shock response and cytoprotection. PLoSONE, 3(8):e2864. doi: 10.1371/

  journal.pone.0002864.

  62. Lu J, Gosslau A, Liu A Y-C and Chen KY (2008) PCR differential display-based identification of

  regulator of G protein signaling 10 as the target gene in human colon cancer cells induced by

  black tea polyphenol theaflavin monogallate. European Journal of Pharmacology 601: 66-72.

  63. Lee YK, Liu DJ, Lu J, Chen KY, and Liu, AY-C. (2009) Aberrant regulation and modification of

  heat shock factor 1 in senescent human diploid fibroblasts. J. Cellular Biochemistry 106:267-278.

  64. Gosslau A, Jao DL, Butler R, Liu AY-C, Chen KY. (2009) Thermal killing of human colon cancer

  cells is associated with the loss of eukaryotic initiation factor 5A. Journal of Cellular Physiology,

  219:485-493.

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